A number of the world's leading synchrotron radiation facilities, forefront science laboratories and international organizations have signed Memoranda of Understanding (MoUs) or Collaborative Agreements with SESAME.

These MoUs and Collaborative Agreements set a framework through which SESAME may be provided with expert advice for construction of its Machine and elaboration of its Science Programme; joint dedicated tasks may carried out; equipment may be donated to SESAME; and placements and funding for Training at advanced synchrotron radiation facilities may be put at the disposal of SESAME.

MoUs and Collaborative Agreements have been signed with:

1. CCLRC (The Science and Technology Facilities Council for the Central Laboratory of the Research Councils)
2. CELLS-ALBA (Consorci per a la Construcció Equipament i Explotació del Laboratori de Llum de Sincrotró)
3. CERN (European Organization for Nuclear Research)
4. CLS (Canadian Light Source)
5. EHSC (El Hassan Science City)
6. FCT (Portuguese Foundation for Science and Technology)
7. IAEA (International Atomic Energy Agency)
8. ICTP (Abdus Salam International Centre for Theoretical Physics)
9. NCP (National Center for Physics of Pakistan)
10. NSRRC (National Synchrotron Radiation Research Center)
11. PSI (Paul Scherrer Institute)
12. Sincrotrone Trieste S.C.p.A.
13. SOLEIL Synchrotron