A recently published article of drug interactions with the human Stratum Corneum (SC), shows the pivotal role of the IR beamline of SESAME in enabling a comprehensive investigation into how certain pharmacologically active drugs, designed for transdermal delivery, interact with the protein components of SC. Such interactions are crucial in determining the efficacy of percutaneous absorption, potentially enhancing or retarding the drug's permeation through the skin. Using FTIR microspectroscopy, researchers from the University of Jordan, including teams from the Faculty of Pharmacy at Philadelphia University and the School of Pharmacy at the University of Jordan, have delved into the complexities of these interactions. Their focus on the interplay between various losartan salts and SC keratin sheds light on the potential for controlled drug release and the impact on SC's physical barrier properties. The obtained observations highlight the potential use of the IR microspectroscopy technique in screening the effect of variable drug forms on the physical barrier properties of SC, which could be of high value for investigating the percutaneous permeation of substances intended for transdermal/topical delivery.
These findings underscore the importance of SESAME as a hub for groundbreaking research in drug delivery and skin barrier function.
Figure: Interaction of some losartan salts with human stratum corneum protein and its effect on losartan transdermal permeation.
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Mansour RSH, Al Khawaja AY, Hamdan II, Khalil EA (2023) IR microspectroscopic investigation of the interaction of some losartan salts with human stratum corneum protein and its effect on losartan transdermal permeation. PLoS ONE 18(6): e0287267. https://doi.org/10.1371/journal.pone.0287267